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TumorPortal specifications

Information


Unique identifier OMICS_29117
Name TumorPortal
Restrictions to use None
Community driven No
Data access Browse
User data submission Allowed
Maintained Yes

Maintainers


  • person_outline Gad Getz
  • person_outline Eric Lander

Publication for TumorPortal

TumorPortal citations

 (8)
library_books

The spatial organization of intra tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

2017
Nat Commun
PMCID: 5333358
PMID: 28240289
DOI: 10.1038/ncomms14565

[…] Somatic mutation across many cancer types were downloaded from a previous study through http://www.tumorportal.org/ (). HCC data sets were curated from several previous publications. In total, 1,185 data sets (198 from TCGA, 242 from ICGC/French, 514 from ICGC/Japanese including part of a recent WG […]

library_books

Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study

2016
PLoS Med
PMCID: 5140047
PMID: 27923066
DOI: 10.1371/journal.pmed.1002162

[…] The TumorPortal [] reports 37 significantly mutated genes for LUAD based on 398 TCGA samples. A pooled analysis of 412 LUAD samples (including 231 TCGA samples and 181 Broad samples) reported 18 significa […]

library_books

Cooperative genomic alteration network reveals molecular classification across 12 major cancer types

2016
Nucleic Acids Res
PMCID: 5314758
PMID: 27899621
DOI: 10.1093/nar/gkw1087

[…] ublic database (including OMIM (), GAD () and CGC ()); (ii) located in the wide peak regions identified by GISTICv2 () (for genes with CNA); (iii) recurrently mutated genes downloaded from http://www.tumorportal.org/ and identified by MutSigCV/MutSigCL/MutSigFN () (for genes with mutations); (iv) genes with alteration frequency >10% (5% for LAML). These driver genes were termed marker genes (Suppl […]

library_books

Whole exome sequencing and single nucleotide polymorphism array analyses to identify germline alterations in genes associated with testosterone metabolism in a patient with androgen insensitivity syndrome and early onset colorectal cancer

2016
PMCID: 4897824
PMID: 27267075
DOI: 10.1186/s40880-016-0115-1

[…] ritance in Man (OMIM) databases to verify the association between the genes and a CRC predisposition. Genes that were found to be significantly somatically mutated in CRC patients and reported in the TumorPortal website (http://www.tumorportal.org) were included. A final list of 57 genes was used for analysis of the WES data (Additional file : Table S2; Additional file : Tables S3).A network inves […]

library_books

SETD2: an epigenetic modifier with tumor suppressor functionality

2016
Oncotarget
PMCID: 5226616
PMID: 27191891
DOI: 10.18632/oncotarget.9368

[…] arious types of cancer (Table ), and this can be seen as an indication that SETD2 inactivation plays a role in the development of other tumors, albeit with low frequencies in most of them (COSMIC [], Tumorportal [] and cBIOPortal [, ], accessed in January 2016). It should be noted that in many studies it is not clear if the mutation resulted in a bi-allelic inactivation of SETD2. Moreover, the maj […]

library_books

Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma

2015
Br J Cancer
PMCID: 4701993
PMID: 26554648
DOI: 10.1038/bjc.2015.378

[…] utation was detected in lung adenocarcinoma tumour tissues in the TCGA cohort or in lung cancer cell lines in the CCLE cohort. Also, no CDKN3 mutation in lung cancer is found in the Broad Institute's tumorportal database (www.tumorportal.org) (). Thus, the frequent overexpression of CDKN3 in lung cancer is not associated with gene mutation. […]


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TumorPortal institution(s)
Broad Institute of MIT and Harvard, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA; Massachusetts General Hospital, Cancer Center and Department of Pathology, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MA, USA; Massachusetts Institute of Technology, Cambridge, MA, USA

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