Identifies the tissue origin from the somatic mutations of a tumor specimen. TumorTracer uses the point mutation and copy number status of a set of 232 genes recurrently mutated in cancer, as well as the relative frequencies of 96 classes of base substitutions. It can help diagnose cancers of unknown primary origin. The tool is also able to identify the origin of circulating tumor cells or DNA found in blood-based screens.
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark; Inserm Unit U981, Gustave Roussy, Villejuif, France; Department of Medical Oncology, Gustave Roussy, Villejuif, France; Cancer Research UK London Research Institute, London, UK; Children’s Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology ([email protected]), Harvard Medical School, Boston, MA, USA
TumorTracer funding source(s)
This work was supported by the European Commission 7th Framework Programme [HEALTH-2010-F2-259303]; the Danish Council for Independent Research [09-073053/FSS]; the Breast Cancer Research Foundation; the Villum Kann Rasmussen Foundation; the Danish Cancer Society and the Novo Nordisk Foundation.