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TWILIGHT specifications


Unique identifier OMICS_14939
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 2.0
Computer skills Advanced
Version 1.56.0
Stability Stable
stats, graphics, Biobase, grDevices, R(>=2.10), Biobase(>=1.12.0), splines(>=2.2.0), stats(>=2.2.0), golubEsets(>=1.4.2), vsn(>=1.7.2)
Maintained Yes




No version available



  • person_outline Volker Brendel

Publication for TWILIGHT

TWILIGHT citations


Network Modeling Identifies Molecular Functions Targeted by miR 204 to Suppress Head and Neck Tumor Metastasis

PLoS Comput Biol
PMCID: 2848541
PMID: 20369013
DOI: 10.1371/journal.pcbi.1000730

[…] on in both GSE6631 and GSE2379 (data not shown). An empirical Student T-test for unequal variances was performed to compare Δ for each microRNA between cancer and normal tissue (Bioconductor package twilight, 1,000 permutation resampling, “paired t-test”for GSE6631, “unpaired t-test” for GSE2379 ). To adjust for multiple comparisons (different microRNAs on the same dataset), we calculate a Benjam […]


From protein interactions to functional annotation: graph alignment in Herpes

BMC Syst Biol
PMCID: 2607256
PMID: 18957106
DOI: 10.1186/1752-0509-2-90

[…] roteins have an amino acid sequence identity of only about 20%. Moreover, many open reading frames are only about 60 amino acids long. Thus, the sequence similarity between the two species is in the 'twilight zone' of detection by alignment, i.e., orthologous open reading frames have alignment scores just marginally above the background of unrelated sequences.To improve the cross-species compariso […]


A constrained polynomial regression procedure for estimating the local False Discovery Rate

BMC Bioinformatics
PMCID: 1940264
PMID: 17603882
DOI: 10.1186/1471-2105-8-229

[…] t's statistic. Then, we estimated lFDR from our procedure, referred to as polfdr, and the four procedures presented in the background section, referred to as locfdr (Efron), LocalFDR (Aubert et al.), twilight (Scheid and Spang), pava.fdr (Broberg). Although these procedures were not designed to estimate the probability π0 independently of lFDR, we also compared the estimators of π0 obtained from t […]


A comparative review of estimates of the proportion unchanged genes and the false discovery rate

BMC Bioinformatics
PMCID: 1199583
PMID: 16086831
DOI: 10.1186/1471-2105-6-199

[…] bum.FDR)2. BH FDR (based on LSL and function fdr.control).3. SPLOSH FDR (based SPLOSH;function splosh)4. smoother FDR or R function qvalue [] (based on the smoother)5. SEP fdr (based on SEP;function twilight)6. the new method pava FDR (based on PRE;function pava.fdr)For brevity mgf, PRE and pava FDR will all be referred to as new methods. It would be more exhaustive to say that PRE is a minor mod […]


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TWILIGHT institution(s)
Max Planck Institute for Molecular Genetics, Computational Diagnostics, Berlin, Germany
TWILIGHT funding source(s)
This work was supported by BMBF grants 031U109C and 03U117.

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