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SynLethDB / Synthetic Lethality DataBase

A comprehensive database of synthetic lethality (SL). SL pairs were collected from multiple sources, including biochemical assays, other related databases, computational predictions and text-mining outputs for five species. Furthermore, a user-friendly web interface has been implemented to facilitate data analysis and interpretation. With the integrated data sets and analytics functionalities, SynLethDB would be a useful resource for biomedical research community and pharmaceutical industry.

Isobase / IsoRank PPI Network Alignment Based Ortholog Database

A database identifying functionally related proteins, across five major eukaryotic model organisms: Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, Mus musculus and Homo sapiens. Nearly all existing algorithms for orthology detection are based on sequence comparison. The IsoBase database may be browsed for functionally related proteins across two or more species and may also be queried by accession numbers, species-specific identifiers, gene name or keyword.

pevoSOAR / Pocketbased EVOlutionary Search Of Amino acid Residues

A method based on comparing similarity of protein surfaces. PEVOSOAR predicts protein functions by solving the problem of uncovering residue substitution pattern due to protein function and separating it from substitution pattern due to protein folding. This method also computes a profile which characterizes protein binding activities that may involve multiple substrates or ligands. PEVOSOAR correctly identified 131 structures as alpha amylase.