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PEDAL / Promoter-Enhancer Discriminative AnaLysis
A computational framework for distinguishing effectively transcriptional profiles of promoters and enhancers. PEDAL uses solely histone modification marks, chromatin accessibility and binding sites of transcription factors and co-activators. It can identify successfully the transcription response subclasses of promoters and enhancers from two different stimulations. PEDAL will be readily incorporated into large-scale analyses aiming at identifying more general rules, if any, that can link local chromatin environment characteristics with different expression programs in mammalian cells.
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