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UniHI specifications


Unique identifier OMICS_01911
Name UniHI
Alternative name Unified Human Interactome
Restrictions to use None
Maintained No


  • Primates
    • Homo sapiens

Publication for Unified Human Interactome

UniHI citations


Complementary Post Transcriptional Regulatory Information is Detected by PUNCH P and Ribosome Profiling

Sci Rep
PMCID: 4761937
PMID: 26898226
DOI: 10.1038/srep21635

[…] urces (including HPRD, BioGrid, IntAct, DIP, BIND and Reactome databases; as well as four interaction maps produced by computational predictions and two high-throughput yeast-2-hybrid (Y2H) screens), UniHI 7 also comprises curated transcriptional regulatory interactions from three complementary databases TRANSFAC, miRTarBase and HTRIdb. Since UniHI 7 is in Entrez gene ID format, we converted to En […]


A visual review of the interactome of LRRK2: Using deep curated molecular interaction data to represent biology

PMCID: 4415485
PMID: 25648416
DOI: 10.1002/pmic.201400390

[…] Interaction rEference (HIPPIE) ) or by adding computationally predicted unexplored interactions based on the experimental data (Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) , Unified Human Interactome (UniHI) ). However, the need to reconcile different representation strategies often results in the sacrifice of detailed information unique to specific databases.Data integra […]


Attenuated Monocyte Apoptosis, a New Mechanism for Osteoporosis Suggested by a Transcriptome Wide Expression Study of Monocytes

PLoS One
PMCID: 4319757
PMID: 25659073
DOI: 10.1371/journal.pone.0116792

[…] have potential roles in regulating expression of the DAXX and PLK3 genes.A classical pathway for osteoblast precipitated osteoclast activity is through RANKL-RANK and RANKL-OPG interactions []. Using UniHI7 [], a database for human molecular interaction networks, we retrieved the potential interacting partners of RANKL, RANK and OPG. Among these retrieved interactions, two interacting partners of […]


ID helix loop helix proteins as determinants of cell survival in B cell chronic lymphocytic leukemia cells in vitro

Mol Cancer
PMCID: 4320821
PMID: 25644253
DOI: 10.1186/s12943-014-0286-9

[…] e []. Candidate apoptosis target genes were further investigated for protein-protein interactions using the ‘String’ (v9.1) database [] and for literature-validated regulatory interactions using the ‘Unified Human Interactome’ (UniHI) database []. A network graph was constructed and visualised using Cytoscape v2.8 []. […]


Drug Like Protein–Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology

Mol Inform
PMCID: 4160817
PMID: 25254076
DOI: 10.1002/minf.201400040

[…] or curated from the scientific literature, 24 data sources contain computational predictions, and 2 data sources can be used for scoring the quality of the interactions.[] Another example is UniHI 7 (Unified Human Interactome). The online tool integrates about 350 000 molecular interactions for more than 30 000 human proteins. Besides protein–protein interactions from 12 different resources (inclu […]


Proteomic Shifts in Embryonic Stem Cells with Gene Dose Modifications Suggest the Presence of Balancer Proteins in Protein Regulatory Networks

PLoS One
PMCID: 2077926
PMID: 18043732
DOI: 10.1371/journal.pone.0001218

[…] ase (www.hprd.org) was used to access the number of direct protein interaction partners. Batch searches of overall protein-protein interaction network information were performed via the meta-database UniHi (http://theoderich.fb3.mdc-berlin.de:8080/unihi). Subsequently, information originating from HPRD, BIND, DIP and Reactome, which are curated manually, was extracted. The visualization of the pro […]


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UniHI institution(s)
Centre for Molecular and Structural Biomedicine, University of Algarve, Faro, Portugal; Institute for Theoretical Biology, Charité, Humboldt-University, Berlin, Germany

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