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UniProt-GOA specifications


Unique identifier OMICS_06216
Name UniProt-GOA
Alternative names The UniProt-Go Annotation database, GOA, Gene Ontology Annotation Database
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes


  • person_outline Rachael P. Huntley

Additional information


Publications for UniProt-GOA

UniProt-GOA citations


First comprehensive analysis of lysine acetylation in Alvinocaris longirostris from the deep sea hydrothermal vents

BMC Genomics
PMCID: 5946511
PMID: 29747590
DOI: 10.1186/s12864-018-4745-3

[…] Different databases were selected for protein functional annotation. Gene Ontology (GO) annotation proteome was derived from the UniProt-GOA database (http://www.ebi.ac.uk/GOA/). If the proteins were not annotated by UniProt-GOA database, the InterProScan (https://www.ebi.ac.uk/interpro) would be applied to annotate by protein […]


Lysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis

PMCID: 5861037
PMID: 29559631
DOI: 10.1038/s41426-018-0032-2

[…] han 1.5 was considered to be upregulated, while a quantitative ratio of <0.67 was considered to be downregulated for the bioinformatics analysis. GO annotation of the proteome was performed using the UniProt-GOA Database (http://www.ebi.ac.uk/GOA/). Proteins were categorized into biological processes and molecular functions according to the GO annotation. The KEGG was utilized to annotate pathways […]


Systematic analysis of the lysine malonylome in common wheat

BMC Genomics
PMCID: 5859436
PMID: 29558883
DOI: 10.1186/s12864-018-4535-y

[…] The malonylated proteins were analyzed by Gene Ontology (GO) annotation derived from the UniProt-GOA database (http://www.ebi.ac.uk/GOA/) based on biological process, cellular component and molecular function []. InterPro (http://www.ebi.ac.uk/interpro/) was used to annotate functional do […]


Integrative analysis of large scale transcriptome data draws a comprehensive landscape of Phaeodactylum tricornutum genome and evolutionary origin of diatoms

Sci Rep
PMCID: 5859163
PMID: 29556065
DOI: 10.1038/s41598-018-23106-x
call_split See protocol

[…] e for exon-skipping or intron-retention. Genes were clustered based on conditions used to prepare the RNA-Seq samples and gene ontology (GO) terms were assigned to the genes (wherever possible) using UniProt-GOA (http://www.ebi.ac.uk/GOA). Significance of these terms was interpreted by calculating the observed to expected ratio of their percent occurring enrichment. The occurrence of an individual […]


Transcriptome and Cell Physiological Analyses in Different Rice Cultivars Provide New Insights Into Adaptive and Salinity Stress Responses

Front Plant Sci
PMCID: 5844958
PMID: 29556243
DOI: 10.3389/fpls.2018.00204

[…] To expand the functional annotation of rice genes, the entire set of transcripts was annotated with the Argot web server (, ; ), which assigned Gene Ontology terms to each input sequence (Gene Ontology Annotation database downloaded on 2013-12-29, PFAM release 27.0). This procedure provided novel annotations for many genes with unknown function (Supplementary Table ). […]


First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos

Sci Rep
PMCID: 5827021
PMID: 29483630
DOI: 10.1038/s41598-018-22069-3

[…] Gene Ontology (GO) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. The GO annotation proteome was determined using the UniProt-GOA database (http://www.ebi.ac.uk/GOA/). Identified protein IDs were converted to UniProt ID and then mapped to GO IDs. If proteins were not annotated in the UniProt-GOA database, InterProSca […]


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UniProt-GOA institution(s)
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
UniProt-GOA funding source(s)
Supported by National Human Genome Research Institute of the National Institutes of Health [U41HG006104, U41HG007822 to UniProt and U41HG002273 to GO Consortium]; National Institutes of Health; British Heart Foundation [RG/13/5/30112]; Parkinson’s UK [G-1307]; European Molecular Biology Laboratory (EMBL) core funds.

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