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UniProt specifications


Unique identifier OMICS_02431
Name UniProt
Alternative names Universal Protein Resource, Swiss-Prot
Restrictions to use None
Community driven No
Data access File download, Browse, Application programming interface
User data submission Allowed
Content license CC Attribution
Maintained Yes



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Publications for Universal Protein Resource

UniProt citations


MLL fusion driven leukemia requires SETD2 to safeguard genomic integrity

Nat Commun
PMCID: 5959866
PMID: 29777171
DOI: 10.1038/s41467-018-04329-y

[…] ity was performed. Enrichment was computed with the topGO package from R, using the default algorithm and the annotation file from geneontology.org (18 November 2015). All human proteins in UniProtKB/Swiss-Prot were used as the background population. p-values were corrected for multiple testing using the Benjamini–Hochberg procedure (FDR). Based on functional annotation similarity, unconnected nod […]


Cattle with a precise, zygote mediated deletion safely eliminate the major milk allergen beta lactoglobulin

Sci Rep
PMCID: 5955954
PMID: 29769555
DOI: 10.1038/s41598-018-25654-8

[…] dio software (Version 7.5, Bioinformatics Solutions Inc., Waterloo, Canada). Spectral data were converted to mzXML files using CompassXtract (version 3.1). Peak lists were queried against a UniProtKB/Swiss-Prot (http://www.uniprot.org) Bos taurus database using the database search tools PEAKS DE NOVO sequencing, PEAKS BD (database search), PEAKS PTM (post-transitional modifications) and SPIDER (al […]


Comparative Genomics Reveals the Core Gene Toolbox for the Fungus Insect Symbiosis

PMCID: 5954228
PMID: 29764946
DOI: 10.1128/mBio.00636-18

[…] nextgenusfs/funannotate), employing tools of Augustus (), GeneMark.hmm-ES (), and EVM (). Gene function was inferred from matches to the databases of Pfam (), Merops (), CAZy (), InterProScan (), and Swiss-Prot (). Product descriptions were assigned with homologues with 60% similarity across 60% of the protein length (). CEGMA v2.4.010312 was used to identify the presence of core eukaryotic-protei […]


Rapid labelling and covalent inhibition of intracellular native proteins using ligand directed N acyl N alkyl sulfonamide

Nat Commun
PMCID: 5951806
PMID: 29760386
DOI: 10.1038/s41467-018-04343-0

[…] nt mass accuracy during gradient. The MS data was analysed by Proteome Discoverer 2.2 (Thermo Fisher Scientific). Searches were performed using Sequest HT (Thermo Fisher Scientific) against UniprotKB/Swiss-Prot release 2017-07-05 with a precursor mass tolerance of 10 ppm, a fragment ion mass tolerance of 0.02 Da. Trypsin specificity allowed for up to two miscleavages. TMT labelling on lysine resid […]


Region of Interest analysis using mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue

Sci Rep
PMCID: 5945593
PMID: 29748547
DOI: 10.1038/s41598-018-25817-7
call_split See protocol

[…] missed cleavage = 1. Peptides and proteins were identified using the Paragon algorithm provided with ProteinPilot 4.5 Beta (AB SCIEX, Danaher Corporation, Washington, D.C.) combined with the UniProt-Swiss-Prot database (version 2010-6, Homo sapiens) and sequences of the known contaminants (AB SCIEX). Matches were assigned with a significance threshold of P < 0.05. We performed false discovery rat […]


Transcriptome sequencing and analysis during seed growth and development in Euryale ferox Salisb

BMC Genomics
PMCID: 5944168
PMID: 29743016
DOI: 10.1186/s12864-018-4707-9

[…] De Bruijn and sequencing information.The unigene sequences were annotated using the following public databases: NCBI non-redundant protein sequences (NR) [], Clusters of Orthologous Groups (COG) [], Swiss-Prot [], Kyoto Encyclopedia of Genes and Genomes (KEGG) [], and Gene Ontology (GO) []. The unigene sequences were aligned using BLASTX with an E-value of < 10− 5. If results from the different d […]


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UniProt institution(s)
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK; SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, Geneva, Switzerland; Protein Information Resource, Georgetown University Medical Center, Washington, DC, USA; Protein Information Resource, University of Delaware, Newark, DE, USA
UniProt funding source(s)
Supported by National Eye Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Mental Health of the National Institutes of Health [U24HG007822]; National Human Genome Research Institute [U41HG007822, U41HG002273]; National Institute of General Medical Sciences [R01GM080646, P20GM103446, U01GM120953]; Biotechnology and Biological Sciences Research Council [BB/M011674/1]; British Heart Foundation [RG/13/5/30112]; Open Targets; Swiss Federal Government through the State Secretariat for Education, Research and Innovation; and European Molecular Biology Laboratory core funds.

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