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UniProtKB specifications


Unique identifier OMICS_03878
Name UniProtKB
Alternative name UniProt KnowledgeBase
Restrictions to use None
Maintained Yes


  • person_outline Michele Magrane

Publication for UniProt KnowledgeBase

UniProtKB citations


MLL fusion driven leukemia requires SETD2 to safeguard genomic integrity

Nat Commun
PMCID: 5959866
PMID: 29777171
DOI: 10.1038/s41467-018-04329-y

[…] ork community was performed. Enrichment was computed with the topGO package from R, using the default algorithm and the annotation file from geneontology.org (18 November 2015). All human proteins in UniProtKB/Swiss-Prot were used as the background population. p-values were corrected for multiple testing using the Benjamini–Hochberg procedure (FDR). Based on functional annotation similarity, uncon […]


Targeting G protein coupled receptor signaling at the G protein level with a selective nanobody inhibitor

Nat Commun
PMCID: 5959942
PMID: 29777099
DOI: 10.1038/s41467-018-04432-0

[…] lecular weights and product ion spectra to obtain the amino acid sequence in successive instrument scans. Data were analyzed by using all CID spectra collected in the experiment to search whole mouse UniProtKB databases with the search program Sequest. Search parameters for peptide identification were as follows: minimum precursor mass, 350 Da; maximum precursor mass, 5000 Da; maximum missed cleav […]


Cattle with a precise, zygote mediated deletion safely eliminate the major milk allergen beta lactoglobulin

Sci Rep
PMCID: 5955954
PMID: 29769555
DOI: 10.1038/s41598-018-25654-8

[…] PEAKS Studio software (Version 7.5, Bioinformatics Solutions Inc., Waterloo, Canada). Spectral data were converted to mzXML files using CompassXtract (version 3.1). Peak lists were queried against a UniProtKB/Swiss-Prot (http://www.uniprot.org) Bos taurus database using the database search tools PEAKS DE NOVO sequencing, PEAKS BD (database search), PEAKS PTM (post-transitional modifications) and […]


Rapid labelling and covalent inhibition of intracellular native proteins using ligand directed N acyl N alkyl sulfonamide

Nat Commun
PMCID: 5951806
PMID: 29760386
DOI: 10.1038/s41467-018-04343-0

[…] ain constant mass accuracy during gradient. The MS data was analysed by Proteome Discoverer 2.2 (Thermo Fisher Scientific). Searches were performed using Sequest HT (Thermo Fisher Scientific) against UniprotKB/Swiss-Prot release 2017-07-05 with a precursor mass tolerance of 10 ppm, a fragment ion mass tolerance of 0.02 Da. Trypsin specificity allowed for up to two miscleavages. TMT labelling on ly […]


Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity based anorexia

Sci Rep
PMCID: 5940678
PMID: 29740148
DOI: 10.1038/s41598-018-25548-9

[…] peptide, ±20 ppm (Q-TOF) or ±1,5 Da (Ion Trap); mass tolerance for fragment ions, ±0.06 Da (Q-TOF) or ±0.5 Da (Ion Trap); ESI-QUAD-TOF and/or ESI-TRAP as instrument; taxonomy, mus musculus; database, UniProtKB/Swiss-Prot. Protein matching probabilities were validated if proteins hits satisfied one of following criteria: MASCOT score of >32 (p < 0.01) or >22 (p < 0.05) with identification confidenc […]


Identification of serum proteins AHSG, FGA and APOA I as diagnostic biomarkers for gastric cancer

PMCID: 5925839
PMID: 29719494
DOI: 10.1186/s12014-018-9194-0

[…] spectra were profiled with SEQUEST [v.28 (revision 12), Thermo Electron Corp.] which searched the human International Protein index (IPI) database (IPI human v3.64 fasta with 71,983 entries) and the UniprotKB (http://www.uniprot.org) for peptide-to-spectral matching. To minimize false positives, a decoy database containing all of the reverse protein sequences was added to this database. The searc […]


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UniProtKB institution(s)
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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