Contains information on domain classes and homology blocks and classifies new sequences. VarDom facilitates the development of new approaches in PfEMP1 research and allows better interpretation. It permits to classify new sequences and relate it to other PfEMP1 proteins in seven genomes. The tool is applicable to any protein dataset, and is suitable for compositional analysis of other frequently recombining gene families.
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark; Centre for Medical Parasitology, Department of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
VarDom funding source(s)
Supported by a grant from the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative and by the University of Copenhagen, Program of Excellence (Membrane Topology and Quaternary Structure of Key Parasite Proteins Involved in Plasmodium falciparum Malaria Pathogenesis and Immunity).