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VarElect specifications

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Unique identifier OMICS_12326
Name VarElect
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Lancet Doron

Publication for VarElect

VarElect citations

 (9)
library_books

Using genome wide association studies to identify common QTL regions in three different genetic backgrounds based on Iberian pig breed

2018
PLoS One
PMCID: 5844516
PMID: 29522525
DOI: 10.1371/journal.pone.0190184

[…] using biomart tool from the porcine ensembl database, sscrofa11.1. in order to identify potential candidate genes the function of genes within each of the selected regions (±1mb) were examined using varelect [], string [] babelomics [] and ncbi databases (growth, muscle development and fat metabolism related genes). moreover, additional information of gene expression data from a previous study […]

library_books

Time and polarity dependent proteomic changes associated with homeostatic scaling at central synapses

2018
eLife
PMCID: 5814146
PMID: 29447110
DOI: 10.7554/eLife.33322.026

[…] 0 = 0.05, 250 randomizations), followed by post-hoc fisher lsd p<0.05 (in origin 2015g sr1, originlab), yielding 168 proteins (, , ). significantly regulated proteins were annotated (, ) using the varelect interpretation tool () by lifemap’s genecards suite (). cellular component ontologies enriched in the regulated proteome compared to the 5135 newly synthesized proteins as the background were […]

library_books

Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis

2017
Hum Mol Genet
PMCID: 5886295
PMID: 28521042
DOI: 10.1093/hmg/ddx140

[…] project and esp6500 (). over 200 deleterious variants were identified in each of the five hlhs patients. further selection of these variants was carried out using the lifemap discovery tools [varelect, genecards, malacards (,)] and pubmed using the search terms: cardiomyocytes, hlhs, mitral stenosis, aortic stenosis, bicuspid valve, outflow tract problems, cardiac vasculogenesis, patent […]

library_books

Enrichment of in vivo transcription data from dietary intervention studies with in vitro data provides improved insight into gene regulation mechanisms in the intestinal mucosa

2017
PMCID: 5390468
PMID: 28413565
DOI: 10.1186/s12263-017-0559-1

[…] chemical effector molecules (leukotrienes), or important inhibitors or stimulators of defined transcriptional mechanisms of in vivo pathways (e.g. mtor), were selected using the genotyping programme varelect (lifemap sciences, inc.)., each microarray comparison between an intervention and control treatment was analysed separately to extract degs with a cut-off of p value <0.05 and an absolute […]

library_books

Sideroflexin 3 is an α synuclein dependent mitochondrial protein that regulates synaptic morphology

2017
PMCID: 5278670
PMID: 28049716
DOI: 10.1242/jcs.194241

[…] by ≥15% across two independent technical replicates (table s1). the remaining 200 proteins were submitted to bioinformatics pathway analysis through ingenuity pathway analysis (ipa), david and varelect, revealing a striking enrichment of proteins (74 out of 200) belonging to mitochondrial pathways (; table s1). this provides substantial experimental support for the hypothesis […]

library_books

Benchmarking of Whole Exome Sequencing and Ad Hoc Designed Panels for Genetic Testing of Hereditary Cancer

2017
Sci Rep
PMCID: 5209723
PMID: 28050010
DOI: 10.1038/srep37984

[…] which classified them as high impact (frameshift, nonsense, stop lost/gain, exon/chromosome deletion, canonic splice-site), and directly related to cancer according to the varelect prioritization tool (http://varelect.genecards.org)., putative pathogenic variants confirmation, cosegregation studies and loss of heterezygosity analysis were performed by sanger sequencing […]


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VarElect institution(s)
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel; LifeMap Sciences Ltd, Tel Aviv, Israel; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA; LifeMap Sciences Inc, Marshfield, MA, USA; Toldot Genetics Ltd, Hod Hasharon, Israel; The Genetics Institute, Rambam Health Care Campus, Haifa, Israel; Rappaport School of Medicine, Technion, Haifa, Israel; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
VarElect funding source(s)
Funding for this research was provided by LifeMap Sciences Inc. California (USA), the NHGRI grant U41HG003345 and the Crown Human Genome Center and the Nella and Leon Benoziyo Center for Neurosciences at the Weizmann Institute of Sciences.

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