A free web-based phenotype-dependent NGS variant prioritizer, which leverages the wealth of information in GeneCards and its affiliated databases. VarElect employs GeneCards’ powerful search and scoring capacities, and its algorithm affords inferring direct as well as indirect links between sequenced genes and disease/symptom/phenotype keywords. The indirect links benefit from GeneCards’ excellent capacity to relate genes to each other via numerous annotations. VarElect thus provides a robust facility for ranking genes and pointing out their likelihood to be related to a patient’s disease.
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel; LifeMap Sciences Ltd, Tel Aviv, Israel; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA; LifeMap Sciences Inc, Marshfield, MA, USA; Toldot Genetics Ltd, Hod Hasharon, Israel; The Genetics Institute, Rambam Health Care Campus, Haifa, Israel; Rappaport School of Medicine, Technion, Haifa, Israel; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
VarElect funding source(s)
Funding for this research was provided by LifeMap Sciences Inc. California (USA), the NHGRI grant U41HG003345 and the Crown Human Genome Center and the Nella and Leon Benoziyo Center for Neurosciences at the Weizmann Institute of Sciences.