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Variant identification software tools | RNA sequencing data analysis

Variant identification software tools | RNA sequencing data analysis

Identifying genomic variation is a crucial step for unraveling the relationship between genotype and phenotype and can yield important insights into human diseases. Prevailing methods rely on cost-intensive whole-genome sequencing (WGS) or whole-exome sequencing (WES) approaches while the identification of genomic variants from often existing RNA sequencing (RNA-seq) data remains a challenge because of the intrinsic complexity in the transcriptome.

Source text:
(Piskol et al., 2013) Reliable identification of genomic variants from RNA-seq data. Am J Hum Genet.

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