Various methods dealing with the comparison, annotation, visualization and especially the detection of structural variations (SVs) were published (Lam et al., 2010; Nielsen et al., 2010; Xi et al., 2010). The simulation of SVs is a powerful, quick and inexpensive approach to…
Desktop app
G T A T C G C T A DWGSIM DWGSIM

DWGSIM

Whole genome simulator for next-generation sequencing. DWGSIM generates base…

Whole genome simulator for next-generation sequencing. DWGSIM generates base error qualities based on a parametric model.

Desktop app
G T A T C G C T A profile based… profile based Illumina pair-end Reads Simulator

pIRS profile based Illumina pair-end Reads Simulator

It is developed for de novo data simulation. pIRS uses empirical distribution…

It is developed for de novo data simulation. pIRS uses empirical distribution to reproduce Illumina pair-end reads with real distribution of substitution sequencing errors, quality values and…

Desktop app
G T A T C G C T A SCNVSim SCNVSim

SCNVSim

A tool for simulating somatic CNVs and structure variations SVs. Other than…

A tool for simulating somatic CNVs and structure variations SVs. Other than multiple types of SV and CNV events, the tool is capable of simulating important features related to tumor samples…

Desktop app
G T A T C G C T A simulating Tumour… simulating Tumour samples through Haplotype…

tHapMix simulating Tumour samples through Haplotype Mixtures

A simulation framework that enables the creation of tumour samples with…

A simulation framework that enables the creation of tumour samples with different ploidy, purity and polyclonality features. tHapMix easily scales to simulation of hundreds of somatic genomes, while…

Desktop app
G T A T C G C T A IntSIM IntSIM

IntSIM

An integrated simulation system to simulate common DNA variants and to generate…

An integrated simulation system to simulate common DNA variants and to generate sequencing reads for mixture genomes. IntSIM has three novel features in comparison with other simulation programs: (1)…

Desktop app
G T A T C G C T A VarSim VarSim

VarSim

A framework for assessing alignment and variant calling accuracy in…

A framework for assessing alignment and variant calling accuracy in high-throughput genome sequencing through simulation or real data. In contrast to simulating a random mutation spectrum, it…

Desktop app
G T A T C G C T A SMaSH SMaSH

SMaSH

A benchmarking methodology for evaluating germline variant calling algorithms.…

A benchmarking methodology for evaluating germline variant calling algorithms. Authors generate synthetic datasets, organize and interpret a wide range of existing benchmarking data for real genomes…

Desktop app
G T A T C G C T A Snp, Indel and Cnv Snp, Indel and Cnv

SInC Snp, Indel and Cnv

An open-source variant simulator and read generator capable of simulating all…

An open-source variant simulator and read generator capable of simulating all the three common types of biological variants taking into account a distribution of base quality score from a most…

Desktop app
G T A T C G C T A BAMSurgeon BAMSurgeon

BAMSurgeon

Tools for adding mutations to .bam files, used for testing mutation callers.…

Tools for adding mutations to .bam files, used for testing mutation callers. One of the primary use cases for BAMSurgeon is to test somatic mutation calling methods.

Desktop app
G T A T C G C T A RSVSim RSVSim

RSVSim

Simulates deletions, insertions, inversion, tandem-duplications and…

Simulates deletions, insertions, inversion, tandem-duplications and translocations of various sizes in any genome available as FASTA-file or BSgenome data package. SV breakpoints can be placed…

Desktop app
G T A T C G C T A GenomeSmasher GenomeSmasher

GenomeSmasher

A set of tools used to create diploid fasta files with containing SNPs, indels,…

A set of tools used to create diploid fasta files with containing SNPs, indels, duplications, deletions, and translocations. These FASTA files can then be used in conjunction with next-generation…

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