Vaxign statistics

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Citations per year

Number of citations per year for the bioinformatics software tool Vaxign

Tool usage distribution map

This map represents all the scientific publications referring to Vaxign per scientific context
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Associated diseases

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Vaxign specifications


Unique identifier OMICS_20486
Name Vaxign
Interface Web user interface
Restrictions to use Academic or non-commercial use
Input data Amino acid sequences from one protein or whole genomes, NCBI protein GI, or RefSeq accession number
Input format FASTA
Output format web link
Computer skills Basic
Stability Stable
Registration required Yes
Maintained Yes



  • person_outline Yongqun He

Additional information

Vaxign is part of VIOLIN

Publication for Vaxign

Vaxign citations


Vaccines Meet Big Data: State of the Art and Future Prospects. From the Classical 3Is (“Isolate–Inactivate–Inject”) Vaccinology 1.0 to Vaccinology 3.0, Vaccinomics, and Beyond: A Historical Overview

PMCID: 5845111
PMID: 29556492
DOI: 10.3389/fpubh.2018.00062

[…] ools exist, to aid and assist researchers in vaccine discovery and design (, ). Databases of vaccine candidates, such as MalVac (), or Vaxar (), software tools such as Vaxjo (), VIOLIN (–), NERVE (), Vaxign (), Vacceed (), Jenner-predict server (), EpiToolKit (), iVax (), or VaxiJen (), have been specifically implemented for vaccinology to enable prediction of vaccine antigens or adjuvants.A succe […]


In silico Design, and In vitro Expression of a Fusion Protein Encoding Brucella abortus L7/L12 and SOmp2b Antigens

PMCID: 5840964
PMID: 29531919
DOI: 10.4103/abr.abr_10_17

[…] abortus vaccine strain 19, studied by Bioinformatics analysis of the strain, indicates that Omp2b probably contributes to the attenuation of this mutant. Additionally, analysis of Brucella genome by Vaxign demonstrated that Omp2b is present in B. abortus, B. melitensis, B. suis and B. canis strains that are pathogenic to humans, but absent from Brucella ovis that is nonpathogenic to humans.[] We […]


Promising new vaccine candidates against Campylobacter in broilers

PLoS One
PMCID: 5703506
PMID: 29176789
DOI: 10.1371/journal.pone.0188472

[…] From C. jejuni 81–176 genomic DNA, genes encoding YP_001000437.1, YP_001000562.1, YP_001001115.1, YP_999769.1, YP_999817.1, and YP_999838.1 from the Vaxign database (named YP437, YP562, YP1115, YP9769, YP9817, and YP9838 hereinafter) were amplified by Polymerase Chain Reaction (PCR) (primers listed in ), using the Vent® DNA polymerase (NEB) or the […]


Identification of New Features from Known Bacterial Protective Vaccine Antigens Enhances Rational Vaccine Design

Front Immunol
PMCID: 5662880
PMID: 29123525
DOI: 10.3389/fimmu.2017.01382

[…] dy, we plan to explore the possibility of integrating these significant criteria along with other including MHC-epitope binding and structure on protein selection as vaccine candidates to improve our Vaxign software program (). Even though our analysis focused on bacterial model, some criteria such as AP, signal peptide, transmembrane proteins, and pathogenesis-related conserved domains and biolog […]


Immunoprotective potential of BamA, the outer membrane protein assembly factor, against MDR Acinetobacter baumannii

Sci Rep
PMCID: 5622086
PMID: 28963492
DOI: 10.1038/s41598-017-12789-3

[…] alternate treatment therapy as most of the commonly available antibiotics are not effective now. Singh et al. screened the whole proteome of A. baumannii and selected potential vaccine candidates by Vaxign online tool on the basis of criteria required for an ideal vaccine candidate protein such as their sub-cellular localization, number of trans-membrane helices, adhesion probability, ability to […]


Computational Identification and Characterization of a Promiscuous T Cell Epitope on the Extracellular Protein 85B of Mycobacterium spp. for Peptide Based Subunit Vaccine Design

Biomed Res Int
PMCID: 5376426
PMID: 28401156
DOI: 10.1155/2017/4826030

[…] to assess the antigenicity of Ag85B. For prediction of protective antigens and subunit vaccines, the VaxiJen ( [] system was utilized. Lastly, Vaxign ( [] was used for vaccine target prediction and analysis. The threshold value in VaxiJen was kept at 0.5. After confirmation of the highest antigenicity of Ag85B […]

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Vaxign institution(s)
Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA; Center for Computational Medicine and Biology, University of Michigan Medical School, Ann Arbor, MI, USA
Vaxign funding source(s)
Supported by the Center for Computational Medicine and Bioinformatics (CCMB) at the University of Michigan Medical School, MI, USA; Public Health Service grants AI43363 and AI081062 from the National Institutes of Health.

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