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- person_outline Dmitriy Chudakov
Publication for VDJdb
Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen Reactive T Cell Populations
[…] f patient MM909.24 were sequenced, and all TCRs used for analyses. Public TCRs were assigned using a curated database of TCR sequences with known Ag specificity (). TCR sequences are available at the VDJdb database (): https://github.com/antigenomics/vdjdb-db/issues/243. […]
Computational Strategies for Dissecting the High Dimensional Complexity of Adaptive Immune Repertoires
[…] machine learning but also a problem for network-based approaches, where one wishes to map antigen-specific information onto generated networks (, ). To address this issue for T-cells, Shugay et al. (VDJDB) and Tickotsky et al. (McPAS-TCR) have built dedicated and curated databases. VDJDB gathers >20,000 unique TCR sequences from different species associated with their epitope (>200) and MHC conte […]
The 2018 Nucleic Acids Research database issue and the online molecular biology database collection
[…] ge through a transmembrane protein. Certain protein classes or families justify their own bespoke databases through medical or biological importance. T-cell receptors are served in this issue by both VDJdb (), focussing on receptor sequences of known specificity, and STCRDab () which collects and curates structural information, linking to and allowing searches against a wide variety of structural, […]
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