Allows to proceed analysis of heavy chain joints. VDJsolver is based on a maximum-likelihood method which takes the lengths of the joint and the mutational status of the VH gene into account. It has a higher predictive performance for D-gene assignment in mutated and unmutated sequences than four other programs. It accepts bulk submissions and is able to analyse rearrangements to all the VH genes from the IMGT database.
Department of Clinical Immunology, Odense University Hospital, Odense, Denmark; Center for Biological Sequence Analysis, BioCentrum, Technical University of Denmark, Lyngby, Denmark
VDJsolver funding source(s)
Supported by grants from the Danish Medical Research Council (grant 22-01-0156), the Institute of Clinical Research, the University of Southern Denmark, the Toyota Foundation, and the Lands-Landsdelspuljen for the County of Funen.