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Veridical specifications

Information


Unique identifier OMICS_02630
Name Veridical
Software type Package/Module
Interface Command line interface
Restrictions to use License purchase required
Operating system Unix/Linux, Mac OS
Programming languages C++
License Commercial
Computer skills Advanced
Maintained Yes

Versioning


No version available

Maintainers


  • person_outline Veridical Team
  • person_outline Peter Rogan

Additional information


This tool is integrated into the MutationForecaster software.

Publication for Veridical

Veridical citations

 (3)
library_books

In silico prediction of splice altering single nucleotide variants in the human genome

2014
Nucleic Acids Res
PMCID: 4267638
PMID: 25416802
DOI: 10.1093/nar/gku1206

[…] o recruit variants that do not cause any alternative splicing. Several attempts have been made to integrate RNA-seq data into in silico tools in order to improve predictions (e.g. SpliceFinder () and Veridical ()). Although their reliability and ease of use require further evaluation, integration of multi-information into one single tool has become a trend.Our dataset was limited to SNVs because t […]

library_books

Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information theoretical analysis

2014
F1000Res
PMCID: 4329672
PMID: 25717368
DOI: 10.5256/f1000research.6038.r6917

[…] eo-Johnson transformation of the expressed read count distribution, parametric statistics are used to compare normal and abnormal mRNA species (exon skipping, intron inclusion, and cryptic site use). Veridical is designed to be used with large data sets, as the statistical analysis gains power with increasing numbers of control samples. A recent study of 442 breast cancer tumors from the Cancer Ge […]

library_books

Splicing mutation analysis reveals previously unrecognized pathways in lymph node invasive breast cancer

2014
Sci Rep
PMCID: 4231324
PMID: 25394353
DOI: 10.1038/srep07063

[…] d bmr calc-covg. All FDRs that we report pertaining to the MuSiC analysis used the Fisher's combined P-value (FCPT), convolution (CT) and likelihood ratio (LRT) statistical tests.The software program Veridical was used for in silico validation of all predicted splicing mutations using its default settings. At the time the program was run, Veridical rounded p-values to 2 decimal places. Validated r […]

Citations

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Veridical institution(s)
Department of Computer Science, University of Western Ontario, London, ON, Canada; Department of Biochemistry, University of Western Ontario, London, ON, Canada; Cytognomix, Inc., London, ON, Canada
Veridical funding source(s)
Supported by the Canadian Breast Cancer Foundation, Canadian Foundation for Innovation, Canada Research Chairs Secretariat and the Natural Sciences and Engineering Research Council of Canada (NSERC Discovery Grant 371758-2009); by fellowships from the Ontario Graduate Scholarship Program, the Pamela Greenaway-Kohlmeier Translational Breast Cancer Research Unit, the CIHR Strategic Training Program in Cancer Research and Technology Transfer, and the University of Western Ontario.

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