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VirHostNet specifications


Unique identifier OMICS_01910
Name VirHostNet
Alternative name Virus-Host Network
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Version 2.0
Maintained Yes


  • Primates
    • Homo sapiens

Publications for Virus-Host Network

VirHostNet citations


Protein–Protein Interactions in Virus–Host Systems

Front Microbiol
PMCID: 5562681
PMID: 28861068
DOI: 10.3389/fmicb.2017.01557

[…] solved PDB structures, which are classified by viral/host taxonomy, GO terms, protein domains, among other biological information.Viral and host PPI data can be retrieved from multiple databases, but VirHostNet (Guirimand et al., ) and VirusMentha (Calderone et al., ) are databases entirely dedicated to virus–host interactions. Most of their entries come from external and semi-independent sources, […]


Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism

PLoS Pathog
PMCID: 5352148
PMID: 28257516
DOI: 10.1371/journal.ppat.1006256

[…] that contained the hub node UBC and computed node and edge frequencies with the 131 remaining forests.We supplemented the PCSF union network with KSHV-human protein-protein interactions obtained from VirHostNet 2.0 [, ] (downloaded January 7, 2016). We considered only latency-related KSHV genes as defined by Davis et al.: K1 (K1_HHV8P), K2 (VIL6_HHV8P), K12A (K12_HHV8P), K12B, K12C, ORF71 (VFLIP_H […]


HVint: A Strategy for Identifying Novel Protein Protein Interactions in Herpes Simplex Virus Type 1*

PMCID: 5013309
PMID: 27384951
DOI: 10.1074/mcp.M116.058552

[…] The HVint database was populated with non-redundant PPI data collated from five different public resources (IntAct, VirHostNet 2.0, DIP, BioGRID and PDB). In doing so, we distinguished between two different sets of PPI data: (1) PPIs directly reported in HSV-1 and (2) PPIs reported in other human herpesviruses spec […]


Novel insights into human respiratory syncytial virus host factor interactions through integrated proteomics and transcriptomics analysis

PMCID: 4819838
PMID: 26760927
DOI: 10.1586/14787210.2016.1141676

[…] host factors that are common to two or more studies to the human protein–protein interaction database (HIPPIE) ( [] and the virus–host interaction database, VirHostNet v2.0 ( []. Interactors of RSV proteins identified in recent studies are also included in the network [–]. In order to minimize false positives and to ensure meaningful i […]


Application of Functional Genomics for Bovine Respiratory Disease Diagnostics

Bioinform Biol Insights
PMCID: 4620937
PMID: 26526746
DOI: 10.4137/BBI.S30525

[…] ogen interaction networks, availability of such HPI data is a prerequisite. Although a number of interaction databases for HPI exist, they are primarily focused on human pathogens. One such resource, VirHostNet,, is a database of curated virus–host molecular interaction data. At present, VirHostNet has only seven HPIs for BVDV and three HPIs for BHV, with very limited number of HPIs. We developed […]


Spillover and pandemic properties of zoonotic viruses with high host plasticity

Sci Rep
PMCID: 4595845
PMID: 26445169
DOI: 10.1038/srep14830
call_split See protocol

[…] ween high-risk disease transmission interfaces involving wildlife. Betweenness centrality was measured for all viruses to indicate the number of connections with wild and domestic animal hosts in the virus-host network, along with the centrality of each virus within the host network, relative to all other zoonotic viruses. Betweenness centrality for each virus was calculated as the number of geode […]


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VirHostNet institution(s)
PRABI, Rhône Alpes Bioinformatics Center, UCBL, Lyon1, Université de Lyon, Lyon, France; UMR5558, UCBL, Lyon1, Université de Lyon, Lyon, France
VirHostNet funding source(s)
Supported by the Fondation INNOVations en Infectiologie (FINOVI) [R12128CC].

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