A genome browser focusing on the human epigenome. The Browser is web-based and it extends the seminal concept invented by the UCSC Cancer Genomics Browser to support large, sequencing-based datasets. Epigenomic measurements are displayed as genome-heatmaps where color gradients reflect strength of the signal. Metadata such as cell type, assay type, epigenetic mark and phenotype of the sample are encoded numerically and displayed in different colors by a “metadata heatmap” alongside the genome-heatmap. Investigators can zoom and pan in a “Google Maps”-like style to examine dozens to hundreds of datasets at any level of detail from single nucleotides up to whole-genome, including a bird’s eye view.