WaveCrest protocols

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WaveCrest statistics

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Associated diseases

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WaveCrest specifications


Unique identifier OMICS_18542
Name WaveCrest
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Input data Some expression matrix, with genes in rows and cells as columns.
Input format CSV
Output data Some normalized expression matrix with genes in row and cells in column following original cell order, cells following recovered order and y-axis shows normalized expression, genes (non-marker) are listed with their corresponding mean squared errors (MSEs).
Output format CSV, PDF, TXT
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License Apache License version 2.0
Computer skills Medium
Stability Stable
Maintained Yes



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  • person_outline Li-Fang Chu <>
  • person_outline James Thomson <>

Publication for WaveCrest

WaveCrest in pipeline

PMCID: 5746276
PMID: 29240790
DOI: 10.1371/journal.pbio.2004050

[…] gene clusters. the cyclic orderings were used to identify additional genes following the same orders by fitting a third-degree polynomial to all genes using the wavecrestiden function from the wavecrest [] r package version 0.0.1. genes were ranked by their fit using the mean squared error (mse), and only the top 100 genes were considered further. the wavecrestiden function was run twice, […]

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WaveCrest in publications

PMCID: 5852448
PMID: 29439542
DOI: 10.3390/jcm7020032

[…] are awaited on this device to help determine its role in laa closure., there are several other devices which are being evaluated to determine their suitability for closing the laa. the coherex wavecrest device was approved for use in europe, but is no longer available []. several others such as the lambre and aegis devices are currently undergoing evaluation., non-pharmacologic treatment […]

PMCID: 5791502
PMID: 29336404
DOI: 10.4103/aca.ACA_111_17

[…] regurgitation or regional wall-motion abnormality of the lateral wall due to lcx compression to be excluded [videos and ]., various devices like watchman, amplatzer cardiac plug [], and coherex wavecrest are available.[] surgical/thoracoscopic la appendectomy and the epicardial lariat suture delivery device are also described.[] watchman is us fda approved device for nvaf […]

PMCID: 5746276
PMID: 29240790
DOI: 10.1371/journal.pbio.2004050

[…] encoding metabolic enzymes (). second, we sought other rnas whose patterns varied in accordance with rps. unstressed cells were ordered based on five representative rp transcripts using the wavecrest algorithm [], which then identified other mrnas whose profiles fluctuated according to the same cell ordering (but not necessarily the same abundance profile, see ). out of the top […]

PMCID: 5264548
PMID: 28243428
DOI: 10.4081/cp.2017.898

[…] to prevent thromboembolism but soft tissue approximation is approved by us-fda. it has 3 components consisting of occlusion balloon catheter, magnet tipped guide wires and suture delivery device., wavecrest device is an alternative to the watchman if laa is very small to accommodate other devices. its advantage is due to the fact that a foam layer covers it on the laa side and ptfe on the side […]

PMCID: 4979802
PMID: 27495048
DOI: 10.1097/MD.0000000000004382

[…] percutaneous left atrial appendage transcatheter occlusion (plaato), amplatzer cardiac plug device (acp), and watchman. other devices included nondedicated amplatzer occluders (ndas), amulet, and wavecrest. the related information and events of laa closure were extracted and listed in table 3s and table . there were 4 studies which reported the outcomes of 2 different devices separately […]

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WaveCrest institution(s)
Morgridge Institute for Research, Madison, WI, USA; Department of Cell & Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA; Department of Molecular, Cellular, & Developmental Biology, University of California, Santa Barbara, CA, USA; Department of Statistics, University of Wisconsin, Madison, WI, USA; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA; Present address: Genentech, Inc., South San Francisco, CA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA
WaveCrest funding source(s)
Supported by the National Institutes of Health 4UH3TR000506-03, 5U01HL099773-06, GM102756, U54 AI117924 and the Charlotte Geyer Foundation, and the Morgridge Institute for Research.

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