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A web-based tool to analyse genes impacted by mutations and rank them through the integration of existing prioritisation tools, which assess different aspects of gene pathogenicity using population-level sequence data. Additionally, to explore the polygenic contribution of mutations to disease, WGPA implements gene set enrichment analysis to prioritise disease-causing genes and gene interaction networks, therefore providing a comprehensive annotation of personal genomes data in disease.

Web user interface
Restrictions to use:
Input data:
Mutated genes, mutated gene-sets, protein substitutions, gene networks
Computer skills:
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  • Enrico Petretto <enrico.petretto at duke-nus.edu.sg>


School of Engineering, Pablo de Olavide University, Seville, 41013 Spain; Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore

  • (Diaz-Montana et al., 2015) Web-based Gene Pathogenicity Analysis (WGPA): A web platform to interpret gene pathogenicity from personal genome data. Bioinformatics.
    PMID: 26490503
  • Animals
    • Homo sapiens

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