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WeSME specifications

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Unique identifier OMICS_12278
Name WeSME
Alternative name Weighted Sampling based Mutual Exclusivity
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Python
Computer skills Advanced
Stability Stable
Maintained Yes

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  • person_outline Yoo-Ah Kim <>

Publication for Weighted Sampling based Mutual Exclusivity

WeSME in publications

 (3)
PMCID: 5643378
PMID: 29038591
DOI: 10.1038/s41598-017-13650-3

[…] differentially mutated sites of amino acid alterations and differentially mutated protein domains were plotted using mutationmapper (http://www.cbioportal.org/mutation_mapper.jsp) in cbioportal., wesme was used to assess the mutational exclusiveness for each cancer type. after 1000 permutations, exclusive p-values were calculated for each gene pair and each cancer type, and p < 0.05 […]

PMCID: 5469877
PMID: 28659971
DOI: 10.3389/fgene.2017.00083

[…] gene weights (probabilities) for each mutation in each sample, and provides an efficient way to assess the statistical significance of the sets using a saddle-point approximation. similarly, wesme (kim y.a. et al., ) introduces a test which incorporates the mutation rates of patients and genes and uses a fast permutation approach to assess the statistical significance of the sets. timex […]

PMCID: 5482642
PMID: 28415609
DOI: 10.18632/oncotarget.16433

[…] metric and random permutation testing method, a couple of novel probabilistic models evaluating mutual exclusivity for gene modules have been developed, such as muex [], mutex [], comet [], wesme [], wext [], etc. those methods overcome some of the drawbacks of previous exclusivity evaluation method. however, compared to the combinatorial evaluation metric, the probabilistic methods […]


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WeSME institution(s)
NCBI, NLM, NIH, Bethesda, MD, USA; Poolesville High School, Poolesville, MD, USA
WeSME funding source(s)
This work was supported in part by the Intramural Research Program of the National Institutes of Health, National Library of Medicine.

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