Whole-genome sequencing data analysis bioinformatics software tools

Whole genome sequencing (WGS) is the next-generation sequencing technology for a rapid and low cost determining of the full genomic sequence of an organism. Deep sequencing of genomes is important not only to improve our knowledge in life sciences and evolutionary biology but…

WGS analysis steps

Preprocessing & quality control

Data analysis

Annotation & interpretation

File, data & workflows

WGS analysis workflow

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WGS analysis workflow schema

Most recent bioinformatics tools

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LSTrAP
Desktop

LSTrAP Large-Scale Transcriptome Analysis Pipeline

Pre-processes RNA-seq data and maps it to the genome. LSTrAP performs quality…

Pre-processes RNA-seq data and maps it to the genome. LSTrAP performs quality control and produces co-expression networks. It provides functional and comparative genomics data to enable a host of…

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DOMINO
Web

DOMINO

Allows detection of genes associated with dominant disorders. DOMINO is based…

Allows detection of genes associated with dominant disorders. DOMINO is based on linear discriminant analysis (LDA). It can efficiently prioritize candidate genes associated with autosomal dominant…

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Biopipe
Web
Desktop

Biopipe

Facilitates design and implementation of bioinformatics workflows and…

Facilitates design and implementation of bioinformatics workflows and applications, and allows comparison between alternative methods. Biopipe is a Docker-based system to assist the researchers in…

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BisPin
Desktop

BisPin

Maps bisulfite-treated short DNA reads to a reference genome. BisPin is an…

Maps bisulfite-treated short DNA reads to a reference genome. BisPin is an application that supports the hairpin construction strategy and rescores ambiguously mapped reads. It provides biologically…

Most popular analytical software

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SAMtools
Desktop

SAMtools

A suite of programs for interacting with high-throughput sequencing data. It…

A suite of programs for interacting with high-throughput sequencing data. It can manipulate alignments in the SAM/BAM/CRAM formats : reading, writing, editing, indexing, viewing and converting…

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Bowtie
Desktop

Bowtie

A short read aligner that aligns short DNA sequences (reads) to the human…

A short read aligner that aligns short DNA sequences (reads) to the human genome at a rate of over 25 million 35-bp reads per hour. Bowtie indexes the genome with a Burrows-Wheeler index to keep its…

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SNPdryad
Web

SNPdryad

A computational method that can predict deleterious effect of amino acid…

A computational method that can predict deleterious effect of amino acid substitutions occurred in human proteins. SNPdryad outperforms other leading algorithms in accurately predicting deleterious…

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HOMER
Desktop

HOMER Hypergeometric Optimization of Motif EnRichment

A suite of tools for Motif Discovery and next-gen sequencing analysis. HOMER…

A suite of tools for Motif Discovery and next-gen sequencing analysis. HOMER contains many useful tools for analyzing ChIP-Seq, GRO-Seq, RNA-Seq, DNase-Seq, Hi-C and numerous other types of…

Curators for WGS analysis

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