WholeBrain statistics

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Associated diseases

Associated diseases

WholeBrain specifications


Unique identifier OMICS_24763
Name WholeBrain
Software type Framework/Library
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages C, C++, Fortran, R
License GNU General Public License version 3.0
Computer skills Advanced
Stability Stable
Maintained Yes



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  • person_outline Konstantinos Meletis <>

Additional information


Publication for WholeBrain

WholeBrain in publications

PMCID: 5897194
PMID: 29504292
DOI: 10.3988/jcn.2018.14.2.129

[…] patients with mdd., with regard to illness duration, a study that applied linear regression analysis and the tbss toolkit found that a longer illness duration was inversely correlated with the mean wholebrain fa. there are also several lines of evidence that microstructural abnormalities can predict the treatment outcomes when administering antidepressants in mdd. the fa values bilaterally […]

PMCID: 5773558
PMID: 29348440
DOI: 10.1038/s41598-018-19390-2

[…] related to the mmt outcomes,., however, insufficient and inconsistent research on the neural predictors for training outcomes hinders the formulation of any definitive hypothesis. thus, we performed wholebrain voxelwise analyses to assess cerebral gray and white matter predictors of mmt. in the current study, stepwise multiple regression was used to investigate demographical […]

PMCID: 5460055
PMID: 28338916
DOI: 10.1093/scan/nsx006

[…] threshold of p < 0.001, uncorrected. a recent study indicates that this threshold reasonably controls for the family-wise error rate (). based on this, amygdala, striatum, prefrontal and wholebrain clusters of k ≥ 1, 18, 113 and 175 voxels, respectively, were considered statistically significant. coordinates are reported in montreal neurological institute space as [x,y,z] and k […]

PMCID: 5082524
PMID: 27257784
DOI: 10.1002/hbm.23275

[…] previously [nieto‐castañón and fedorenko, ], such an approach affords a greater understanding of inter‐individual consistency that is relatively independent of sample size. for example, the wholebrain random‐effects group analysis alone tells us nothing specific about inter‐subject consistency, just that a point of overlap exists. a probabilistic atlas based on individually defined […]

PMCID: 4959357
PMID: 27453981
DOI: 10.1186/s12938-016-0183-0

[…] and 23 clinical descriptors. biological descriptors are genetic variations of apoe4 related gene, pet imaging results fdg-pet and av45, and mri volumetric data of: ventricles, hippocampus, wholebrain, entorhinal, fusiform gyrus, middle temporal gyrus (midtemp), and intracerebral volume (icv). clinical descriptors are: clinical dementia rating sum of boxes (cdrsb), alzheimer’s disease […]

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WholeBrain institution(s)
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroscience, Scripps Research Institute, Jupiter, FL, USA; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Molecular Medicine, Scripps Research Institute, Jupiter, FL, USA
WholeBrain funding source(s)
Supported by the Swedish Research Council (VR 2012-02049), from the Karolinska Institutet (KID-funding supporting), from the Strategic Neuroscience Area at Karolinska Institutet (StratNeuro) for rabies virus production and from the Swedish Brain Foundation (Hjärnfonden) the National Institute of Mental Health grant (MH109795) and a National Institute on Drug Abuse grant (DA0036376).

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