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Wregex specifications


Unique identifier OMICS_05914
Name Wregex
Alternative name Weighted regular expression
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
License GNU General Public License version 2.0
Computer skills Advanced
Stability Stable
Maintained Yes


No version available


Unique identifier OMICS_05914
Name Wregex
Alternative name Weighted regular expression
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for Weighted regular expression

Wregex citations


Divergent bornaviruses from Australian carpet pythons with neurological disease date the origin of extant Bornaviridae prior to the end Cretaceous extinction

PLoS Pathog
PMCID: 5834213
PMID: 29462190
DOI: 10.1371/journal.ppat.1006881

[…] tiple prediction tools and report candidate NES and NLS that were identified at the same positions in both JCPV and SWCPV proteins. We used NLSmapper and NLStradamus to predict NLS, and NESMapper and Wregex to predict NES [–]. Transmembrane domains were predicted using the TMHMM2.0 web service []. Signal peptides were predicted using the SignalP 4.1 server with the sensitive option enabled []. Put […]


Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease

PLoS Negl Trop Dis
PMCID: 5794198
PMID: 29357372
DOI: 10.1371/journal.pntd.0006180

[…] ot be excluded that DNA intercalation may be contributing to their reported anti-parasitic activity, especially since trypanosomes are susceptible to intercalating agents []. Analysis of TcSir2rp1 by Wregex and cNLS Mapper, bio-computational tools that identify nuclear export signals (NES) and nuclear localization signals (NLS), respectively, indicate the presence of non-canonical NES/NLS in the s […]


Identification of CASZ1 nuclear export signal (NES) reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma

PMCID: 5140774
PMID: 27270431
DOI: 10.1038/onc.2016.179

[…] ative NES is lost or disrupted (CASZ1bΔN186), it allows NLS2 to function to retain the truncated CASZ1b in the nucleus. To test this hypothesis, we performed in silico bioinformatics analysis (http://wregex.ehubio.es/) of CASZ1b using Wregex (weighted regular expression) 1.1 program that has been developed for motif scanning (). It revealed a CRM1 dependent NES motif in CASZ1b (AA176–192) (). Hydr […]


Proteome wide search for functional motifs altered in tumors: Prediction of nuclear export signals inactivated by cancer related mutations

Sci Rep
PMCID: 4865848
PMID: 27174732
DOI: 10.1038/srep25869
call_split See protocol

[…] As shown in , the Wregex 2.0 web interface has been updated to include mutation information from the COSMIC database. When [COSMIC] is enabled as option, two Wregex searches are combined (). A first search for candidat […]


Leukemia Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport

PLoS One
PMCID: 4474691
PMID: 26091065
DOI: 10.1371/journal.pone.0130610

[…] the results above show that CRM1-mediated NPM export is inefficient. In fact, the aminoacid sequence determinants responsible for NPM export are still unclear. Using a new NES-prediction tool, termed Wregex [], we identified a candidate NES motif (268-FINYVKNCFRM-278) in the C-terminal domain of NPM () that has not been previously investigated. However, this predicted NES was found to be inactive […]


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Wregex institution(s)
Department of Communications Engineering, University of the Basque Country (UPV/EHU), Alda Urquijo, Bilbao, Spain; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Barrio Sarriena, Leioa, Spain

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