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ZFN design software tools | Genome engineering

Zinc-finger nucleases (ZFNs) are targetable DNA cleavage reagents that have been adopted as gene-targeting tools. ZFN-induced double-strand breaks are subject to cellular DNA repair processes that lead to both targeted mutagenesis and targeted gene…
ZifNN
Web

ZifNN

Predicts high throughput of optimal zinc finger protein for 9 bp DNA sequences…

Predicts high throughput of optimal zinc finger protein for 9 bp DNA sequences of choice. ZifNN is inspired from an ensemble machine learning approach, and incorporates the predictions made by 100…

ZiF-Predict
Web

ZiF-Predict

Predicts recognition helices for C2H2 zinc fingers that bind to specific target…

Predicts recognition helices for C2H2 zinc fingers that bind to specific target DNA sites. ZiF-Predict is based on artificial neural network using an exhaustive dataset of zinc finger proteins (ZFP)…

PROGNOS
Desktop
Web

PROGNOS Predicted Report Of Genome-wide Nuclease Off-target Sites

Provides a user-friendly, web-based tool for rapid identification of potential…

Provides a user-friendly, web-based tool for rapid identification of potential nuclease off-target cleavage sites that can be evaluated using standard molecular biology techniques. The…

Zinc Finger…
Web

Zinc Finger Tools

This site provides several tools for selecting zinc finger protein (ZFP) target…

This site provides several tools for selecting zinc finger protein (ZFP) target sites and for designing the proteins that will target them.

ZiFiT
Web

ZiFiT Zinc Finger Targeter

A simple and intuitive web-based tool that provides an interface to identify…

A simple and intuitive web-based tool that provides an interface to identify potential binding sites for engineered zinc finger proteins (ZFPs), clustered regularly interspaced short palindromic…

ZFN-Site
Web

ZFN-Site

A web interface that searches multiple genomes for ZFN off-target sites.

A web interface that searches multiple genomes for ZFN off-target sites.

ZFN target…
Web

ZFN target site algorithm

For identifying sites compatible with the Lawson-Wolfe modular assembly system.

For identifying sites compatible with the Lawson-Wolfe modular assembly system.

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