Infers functional miRNA– mRNA regulatory modules (FMRMs), which consist of miRNAs, mRNAs and expression types in each biological class type. The algorithm of Zhang et al. is a probabilistic model, which first uses gene differential expression analysis to find differentially expressed miRNAs and mRNAs, and then infers FMRMs in specific cellular conditions with a probabilistic topic model. This model is closely associated with the latent Dirichlet allocation (LDA) model.
Kunming University of Science and Technology, Kunming, China; School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW, Australia; School of Computer and Information Science, University of South Australia, Australia
ZhangEtAl2012 funding source(s)
Supported by Science Research Foundation of Yunnan Educational Committee (No. 2011J079), Yunnan Fundamental Research Foundation of Application (No. 2009ZC049M), Science Research Foundation of Kunming University of Science and Technology (No. 2009-022), and Science Research Foundation for the Overseas Chinese Scholars, State Education Ministry (No. 2010-1561).